Rationality of Use and Effectiveness of Stress Ulcer Prophylaxis in Critically Ill Patients: An Experience from A Tertiary Intensive Care Unit

Background: Stress-related mucosal disease (SRMD) frequently develops in critically ill patients, increasing mortality and length of intensive care unit (ICU) stay. There is limited data on stress ulcer prophylaxis (SUP) patients Indonesia.Objective:Methods: This a retrospective cohort study admitted to the ICU from January 1, 2015, December 31, 2017. The subjects were all who used proton pump inhibitor (PPI) histamine-2 receptor antagonist (H2RA) as SUP therapy.Results: A total 315 included, mean age was 48 years. Approximately 55.2% women, 62.8% following high-risk surgery. PPI given 187 (59.4%) H2RA 128 (40.6%), with an average usage for 5 days. incidence SRMD 15.9% (n = 50), stay 6 Gender, age, duration SUP, groups not statistically different (p > 0.05) did affect GI event 0.05). use rational 98.4%. Major American Society Health-System Pharmacists (ASHP) risk factor criterion ventilator (86.8%), while minor ASHP anticoagulant therapy (22.2%). significantly lower than < 0.05).Conclusions: are superior prophylaxis.